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/ REFERENCES:

1. Tiktinskiy OL, Aleksandrov VP. Urolithiasis disease. St. Petersburg. Peter, 2000. 384p. Russian ( .., .. . ., , 2000. 384 .).

2. Randall A. Papillary pathology as a precursor of primary renal calculus. J Urol. 1940; (44): 580 589.

3. Evan AP. Phisiopathology and ethiology of stone formation in the kidney and the urinary tract. Pediatr Nephrol. 2010; (25): 831 841.



4. Yagisawa T, Chandhoke S, Fan J, Lucia S. Renal osteopontin expression in experimental urolithiasis. J Endourol. 1998; (12): 171 176.

5. Gurevich LE, Isakov VA. The technique of recovery of antigenic specificity by microwaves generationon the tissues fixed by formalin and paraffin im pregnated in immunohistochemical studies. Arkh.Patol. 1999; (2): 48 50. Russian ( .., .. , // . 1999. 2. . 48 50).

6. Evan AP, Worcester EM, Lingerman JE. Three pathways for human kidney stone formation. Urol Res. 2010; (38): 147 160.

7. Ryall RL. The future of stone research: rummaging in the attic, Randalls plaque, nanobcteria and lessons from phylogeny. Urol Res. 2008; 36(2): 77 97.

8. Motin YuG, Lepilov AV, Bgatova NP, Zharikov AYu, Motina NV, Lapiy GA et al. Endoplasmic reticulum stress development in experimental oxalate nef rolithiasis. Bulletin of Experimental Biology and Medicine. 2015; (9): 369 374. Russian ( .., .., .., .., .., .. . // . 2015. 9. . 369 374).

14.10.2015 .

14.10.2015 .

   

˨ . , () (), 272 300 ().

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. IgA IgG .

. IgG IgA 11,7 % 13,3 % 1,8 % 5,5 % . 7,1 3,7. IgG IgA (9,0 % 4,7 %), (18,0 % 9,2 %). OR 0,8 1,2. IgG IgG (36,6 % 32,8 %). IgA IgA , (56,7 % 46,7 %).

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T. 15 1 2016

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Glushkov A.N., Polenok E.G., Kostyanko M.V., Titov V.A., Vafin I.A., Ragozhina S.E.

Institute of Human Ecology of Siberian Branch of Russian Academy of Sciences, Kemerovo State University, Regional clinical oncology hospital, Regional center of blood, Kemerovo, Russia

ANTIBODIES TO ESTRADIOL AND PROGESTERONE IN HEALTHY MEN AND LUNG CANCER PATIENTS

Objective serum antibodies specific to estradiol (Es) and to progesterone (Pg) in 272 healthy men (HM) and 300 non small cells lung cancer patients (LCP) were studied.

Methods. A semi quantitative non competitive immunoassay of IgA and IgG antibodies to estradiol (IgGEs) and progeste rone (IgGPg) was conducted by using Es and Pg conjugated with bovine serum albumin. ROC analysis was also conducted to determine the odds ratio (OR).

Results. Neither IgA Es no IgA Pg were identified in 38,6 % of HM and 25,3 % of LCP (p = 0,002). Neither IgG Es no IgG Pg were identified in 47,4 % of HM and 42,7 % of LCP (p = 0,3). High levels of IgA Es and IgG Es separately without anti bodies to Pg were determined in 13,3 % and 11,7 % of LCP, but only in 5,5 % and 1,8 % of HM (p = 0,002; p = 0,0005). High levels of IgA Pg and IgG Pg separately without antibodies to Es were determined in 4,7 % and 9,0 % of LCP, but in 9,2 % and 18,0 % of HM (p = 0,3; p = 0,04). Both IgA Es and IgA Pg were found in 56,7 % of LCP and in 46,7 % of HM (p = 0,003).

Both IgG Es and IgG Pg were found in 36,6 % of LCP and in 32,8 % of HM (p = 0,3).

Conclusions. It is supposed, that antibodies to Es may stimulate, but antibodies to Pg may inhibit lung carcinogenesis in men.

Antibodies to Pg reduce the stimulating effects of antibodies to Es when they are formed together.

Key words: lung cancer; antibodies; estradiol; progesterone.

   

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; , , , . , . E mail: kmvksu@mail.ru , . , , . , . E mail: 05 guz okod@kuzdrav.ru , . , , . , . E mail: stpk@kuzdrav.ru , . . , , . , . E mail: ragozhinas@mail.ru

Information about authors:

GLUSHKOV Andrew Ni, MD, PhD, Professor, Director, Institute of Human Ecology, Kemerovo, Russia.

POLENOK Elena G., PhD, Chief of Immunochemistry Laboratory, Department of Molecular Human Ecology, Institute of Human Ecology, Ke merovo, Russia.

KOSTYANKO Mikhail V., Leading Engineer, Department of Organic Chemistry, Kemerovo State University, Kemerovo, Russia.





TITOV Victor A., Chief of Thoracic Department, Regional Clinical Oncology Hospital, Kemerovo, Russia.

VAFIN Ilgis A., Chief, Regional Center of Blood, Kemerovo, Russia.

RAGOZHINA Svetlana E., Vice chief, Regional Center of Blood, Kemerovo, Russia.

   

/ REFERENCES:

Verma MK, Miki Y, Sasano H. Sex steroid receptors in human lung diseases. J. Steroid Biochem. Molecular Biology. 2011; 127(3 5): 216 222.

1.

2. Stabile LP, Davis AL, Gubish CT, Hopkins TM, Luketich JD, Christie N et al. Human non small cell lung tumors and cells derived from normal lung exp ress both estrogen receptor and and show biological responses to estrogen. Cancer Res. 2002; 62(7): 2141 2150.

3. Nowak RA, Wang MW, Hamon MH, Lamb DJ, Bullock DW, Heap RB. Effect of passive immunization against progesterone on its distribution in circu lation and tissues of mice. J. Reprod. Fertil. 1990; 89(2): 671 679.

4. Bourtourault M, Shacoori V, Guerin J, Saiaq B, Rault B. Effects of simultaneous active immunization against 17 beta estradiol and testosterone on pi tuitary and ovarian activity in rat. Res. Commun. Chem. Pathol. Pharmacol. 1991; 72(3): 273 284.

5. Caldwell BV, Tillson SA, Esber H, Thorneycroft IH. Survival of tumors after immunization against estrogens. Nature. 1971; 231(5298): 118 119.

6. Glushkov AN, Polenok EG, Verzhbitskaya NE, Titov VA, Vafin IA, Ragozhina SE. Antibodies to chemical carcinogens and steroid hormones in patients with lung cancer. Russian Immunological Journal. 2014; 8/17(2): 219 227. Russian ( .., .., .., .., .., T. 15 1 2016 105

.. // . 2014. . 8(17), 2. . 219 227).

7. Zweig MH, Campbell G. ROC plots: a fundamental evaluation in clinical medicine. Clinical Chemistry. 1993; 39(4): 561 577.

8. Glushkov AN. Immunological disbalance in carcinogenesis. Medical Hypotheses. 2014; 83: 166 171.

9. Glushkov AN, Krasilnikova KS, Polenok EG, Kostyanko MV. Effect of antibodies to low weight xeno and endobiotics on the concentration of estradi ol and progesterone in serum of pregnant women. News of the Samara Scientific Center of the Russian Academy of Sciences. 2014; 16(5/2): 682 686.

Russian ( .., .., .., .. // . 2014. . 16, 5(2). . 682 686.)

10. Ustinov VA, Matveeva VA, Kostyanko MV, Glushkov AN. Antibodies against benzo[a]pyrene in immunized mouse and lung cancer patients. Experim.

Oncol. 2013; 35(3): 207 210.

11. Glushkov AN. Clinical immunochemistry of carcinogenesis: new challenges and prospects. Russian Immunological Journal. 2013; 7/16(1): 27 34. Rus sian ( .. : // . 2013.

. 7(16), 1. . 27 34.

12. Glushkov AN, Klimov IA, Anosova TP, Schukina ML. Antibodies to polycyclic aromatic hydrocarbons in sera of patients with malignant mammary tu mors. Experim. Oncol. 1996; 18(3): 284 286.

13. Silbart LK, Rasmussen HV, Oliver AR. Immunoprophylactic intervention in chemical toxicity and carcinogenicity. Vet. Hum. Toxicol. 1997; 39(1): 37 43.

14. Grova N, Prodhomme EJ, Schellenberger MT, Farinelle S, Muller CP. Modulation of carcinogen bioavailability by immunization with benzo[a]pyrene conjugate vaccines. Vaccine. 2009; 27: 4142 4151.

15. Cernohorska H, Klimesova S, Lepsa L, Jinoch P, Milcova A, Schmuczerova J et al. Influence of immunization with non genotoxic PAH KLH conjugates on the resistance of organisms exposed to benzo[a]pyrene. Mut. Res. 2012; 742: 2 10.

30.12.2015 .

30.12.2015 .

   

, , 80 %. 5 10 % Q . , , . Q , , .

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Vereshchagin I.E., Vereshchagin M.A., Kovaleva Y.V., Fomkin O.G.

City linical Hospital N 1, Novokuznetsk State Institute of Advanced Training of Physicians, Novokuznetsk, Russia

POSTCONDITIONING MYOCARDIUM DURING PRIMARY PERCUTANEOUS CORONARY INTERVENTION

IN PATIENTS WITH CARDIOGENIC SHOCK

It is known that cardiogenic shock is one of the severe complications of acute myocardial infarction, in hospital mortality in which up to 80 %. Cardiogenic shock occurs in 5 10 % of patients with acute Q wave myocardial infarction is the most com mon cause of death. Reperfusion injury of the myocardium is a syndrome that occurs as a result of the restoration of coro nary blood flow in the ischemic area of the myocardium and myocardial characterized, electrophysiology and vascular dysfun ction. This example describes a clinical case of successful treatment of a patient with acute Q wave posterior myocardial infarction complicated by cardiogenic shock, and clinical death.

Key words: acute myocardial infarction; cardiogenic shock; myocardial reperfusion injury;

coronary artery stenting; myocardial postconditioning.

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